The PREeMPT study
Research type
Research Study
Full title
Is it feasible to conduct a randomised controlled trial of pre-transplant exercise (prehabilitation) for multiple myeloma patients awaiting autologous stem cell transplantation? (PREeMPT study)
IRAS ID
205964
Contact name
Susan Mawson
Contact email
Sponsor organisation
Sheffield Teaching Hospitals NHS Foundation Trust
Duration of Study in the UK
2 years, 6 months, 31 days
Research summary
We propose to determine whether it is acceptable to patients with a diagnosis of multiple myeloma (a type of blood cancer that can cause bone weakness, pain and fatigue) to be offered and attend an exercise group before receiving an autologous stem cell transplantation (being given back one's own stem cells, following receipt of intensive chemotherapy, to enable your bone marrow to start producing blood cells again).
Exercise has been shown to be effective in reducing many of the side effects of myeloma and the treatment patients receive to manage the disease. Prehabilitation i.e. providing an intervention after diagnosis but before treatment begins has been effective in reducing the severity of side
effects of treatment in cancer patients receiving surgery. No evidence exists for its use in patients with myeloma.
Patients awaiting transplantation will be provided with information regarding the study and invited to join. Patients who agree to take part will attend the hospital for an assessment of their exercise capability and to complete one set of four questionnaires. They will receive an exercise booklet, advice and complete one attempt at their exercise programme under supervision of a physiotherapist.
Patients will be requested to attend the gym for a minimum of six further
weeks to complete their exercise programme. Patients will complete a repeat set of questionnaires and a repeat walking test six weeks after the first, on admission to hospital for their transplant and on the day they leave
hospital. Some patients will be invited to discuss their opinions of the exercise programme and how useful they felt it was to them in preparing for their transplant.
If the study shows that the exercise programme is acceptable to patients and we can recruit enough patients to test it in a larger trial, we will apply for further funding.REC name
Yorkshire & The Humber - Bradford Leeds Research Ethics Committee
REC reference
16/YH/0304
Date of REC Opinion
31 Aug 2016
REC opinion
Further Information Favourable Opinion