The OASIS Study
Research type
Research Study
Full title
Optimising Atrial Fibrillation Screening to Prevent Second Ischaemic Strokes (OASIS): a Within-Person Comparison Study of an NT-proBNP Guided Pathway versus Usual Care
IRAS ID
337075
Contact name
Alan Cameron
Contact email
Sponsor organisation
NHS Greater Glasgow and Clyde
Duration of Study in the UK
3 years, 6 months, 0 days
Research summary
Atrial fibrillation (AF) is an irregular heart rhythm that causes blood clots and strokes. Drugs that stop blood clots (anticoagulants) prevent recurrent strokes in people with AF. Heart monitors are worn for 3 days after stroke to find people with AF. The number of people with AF detected after 3 days of heart monitoring is low (4 in 100). Heart monitors that are worn for 28 days find many more people with AF (16 in 100), but 28 day heart monitors are not available in most stroke departments.
We need ways to introduce longer heart monitoring in NHS stroke departments. NT-proBNP is a blood test that is higher in people with AF. NT-proBNP could identify people who will benefit most from longer heart monitoring. This would help introduce longer heart monitoring in the NHS and avoid tests for people who are unlikely to have AF.
We want to know how many stroke survivors with high NT-proBNP are diagnosed with AF by asking them to wear a heart monitor for 28 days. We will include 1172 people attending hospital with a stroke or transient ischaemic attack (TIA). We will collect clinical information and a blood test for NT-proBNP. People will wear a heart monitor for 28 days and we will assess how many people have AF detected after 3 days and 28 days of heart monitoring. We will investigate how many people with high NT-proBNP are diagnosed with AF by a 28 day heart monitor and calculate how many of these people would not be diagnosed with AF by a 3 day heart monitor.
REC name
West of Scotland REC 3
REC reference
24/WS/0163
Date of REC Opinion
11 Dec 2024
REC opinion
Further Information Favourable Opinion