The METRED-P Study [1]
Research type
Research Study
Full title
The Mediterranean diet and Time-Restricted Eating Dietary intervention for Psoriasis (METRED-P) Study.
IRAS ID
315873
Contact name
Wendy Hall
Contact email
Sponsor organisation
King's College London
Clinicaltrials.gov Identifier
Duration of Study in the UK
1 years, 2 months, 1 days
Research summary
The METRED-P study is a randomised controlled trial assessing the feasibility of implementing a Mediterranean style diet (MD) and time-restricted eating (TRE) in individuals with psoriasis. Participants will be randomly allocated to a MD, a MD with TRE, or a UK diet with TRE to adhere to for 12 weeks.
This study is funded by the Psoriasis Association and will contribute to the existing research exploring diet and psoriasis in the aim to derive dietary recommendations for individuals with psoriasis.
Psoriasis is an inflammatory skin condition affecting 2% of the UK population. It is part of a wider health problem as it significantly impacts life quality and is linked with cardio-metabolic disease. There is no cure for psoriasis and as an addition to conventional anti-psoriatic therapies, interest has emerged to introduce dietary advice such that patients can better manage their psoriasis.
The research exploring low calorie, gluten-free, and very low-calorie ketogenic diets, reports favourable effects in relation to improving the severity of psoriasis. There are no clinical studies examining the effect of a MD and TRE patterns on psoriasis severity, which are dietary patterns that reduce inflammation.
Volunteers will be eligible to participate if they are adults (18+ years), male or female, with mild-moderate psoriasis, with a body mass index ≥25 and <40 kg/m2, in absence of underlying health conditions and not taking any light, tablet or injection treatments for psoriasis.
The study will be conducted at King’s College London. Participants will attend a clinic visit at baseline for a fasting blood sample, psoriasis examination, blood pressure and body composition measurements. The diet interventions will be delivered by a Research Nutritionist as reoccurring 1:1 consultation sessions over 12 weeks. At the end of the study, participants will attend a final clinic visit to repeat the measures obtained at baseline.
REC name
London - London Bridge Research Ethics Committee
REC reference
23/LO/0696
Date of REC Opinion
13 Sep 2023
REC opinion
Further Information Favourable Opinion