The Maraviroc CNS Study

• Research type

  Research Study

• Full title

  The penetration of maraviroc into the central nervous system in HIV-1 infected subjects on stable antiretroviral therapy; a phase I pharmacokinetic study.

• IRAS ID

  16628

• Eudract number

  2008-008437-10

• ISRCTN Number

  not issued

• Research summary

  To describe the CNS exposure of maraviroc in HIV-1 infected subjects receiving a stable antiretroviral regimen, including maraviroc, at steady state.HIV related brain disease (HIV Dementia) remains prevelant. Antiretroviral drugs which penetrate the central nervous system may prevent this dementia process. The aim of this study is to assess the penetration of maraviroc, a new antiretroviral (anti-HIV) agent, into the central nervous system.

• REC name

  London - West London & GTAC Research Ethics Committee

• REC reference

  09/H0707/35

• Date of REC Opinion

  23 Jun 2009

• REC opinion

  Further Information Favourable Opinion