The Incremental Role of CMR in MINOCA
Research type
Research Study
Full title
The incremental role of cardiac magnetic resonance imaging in myocardial infarction with non-obstructive coronary arteries
IRAS ID
244996
Contact name
Chiara Bucciarelli-Ducci
Contact email
Sponsor organisation
University of Bristol
Duration of Study in the UK
2 years, 0 months, 1 days
Research summary
Heart attacks are the leading cause of death worldwide. In up to 10% of patients a heart attack is not caused by a blocked or narrowed heart artery. This condition is called 'myocardial infarction (heart attack) with non-obstructive coronary arteries' (MINOCA). It is important to recognise because it is often misdiagnosed and has a significant death rate. There are three main causes: i) acute myocarditis (heart inflammation) ii) cardiomyopathy (heart muscle disease) iii) a heart attack caused by a temporary blockage of an artery. Correctly identifying them has significant impacts for patient management. Cardiac magnetic resonance imaging (CMR) has emerged as a valuable diagnostic tool and the faster the scan is performed, the more likely the scan will make a diagnosis. In the proposed study we will look at a prospective cohort of patients with MINOCA presenting to a tertiary cardiac centre in the South-West of England. In addition to standard care we will offer sequential cardiac MRI scans, using novel sequences, to patients over a 6-month period. The main aim is to show that CMR has an incremental diagnostic role over standard care and changes patient management.
In addition to the main study we will be offering sequential brain MRI and blood tests to help us understand why different patients get these conditions. We will be using control patients who have had a heart attack due to a blocked coronary artery so we have a comparison group.REC name
South Central - Hampshire B Research Ethics Committee
REC reference
18/SC/0380
Date of REC Opinion
15 Aug 2018
REC opinion
Further Information Favourable Opinion