The impact of the pH on cardiac function in the critically ill patient
Research type
Research Study
Full title
The impact of systemic pH on cardiac function and clinical outcome in the critically ill patient
IRAS ID
227870
Contact name
Sancho Rodriguez-Villar
Contact email
Sponsor organisation
The R&I OfficeKing’s College Hospital NHS Foundation Trust
Duration of Study in the UK
1 years, 0 months, 0 days
Research summary
Titration studies in animals with normal cardiac function show that a reduction in blood pH (and presumably that of the intracellular and interstitial compartments) from the normal level of 7.40 to 7.20 is associated with a rise in cardiac output. However, when blood pH is less than 7.20, cardiac output is reduced. Similar studies in humans with or without normal cardiac function have not been done, and yet blood pH at which aggressive treatment is recommended has been set at 7.20 based solely on animal experiments. We hypothesize that a change in blood pH in humans will also affect cardiac function, but the level of blood pH at which this is observed might be similar or different in humans. In addition, the presence or absence of underlying cardiac disease and the type of acid-base abnormality present might modify the response of the heart to changes in blood pH.
This is an observational study of routinely collected clinical data.
The study will be conducted in two NHS Trusts. Across King's College NHS Foundation Trust and Lewisham and Greenwich NHS Trust there are seven different Intensive Care Units´s: King´s College Hospital (4 units), Princess Royal University Hospital (in Orpington), Lewisham University Hospital (Lewisham)and Queen Elizabeth Hospital (Woolwich).
Data will be collected prospectively. The data will be sourced from the medical notes and ICU charts. All data will be collected by the direct care team. There is no intervention or additional tests.
REC name
East Midlands - Leicester South Research Ethics Committee
REC reference
18/EM/0138
Date of REC Opinion
2 May 2018
REC opinion
Favourable Opinion