The impact of Intraventricular Haemorrhage on Brain Development
Research type
Research Study
Full title
Understanding the impact of Intraventricular Haemorrhage on Brain Development in the Premature Neonates. (SOLVe Trial: Sampling of Lateral Ventricle)
IRAS ID
247396
Contact name
Martin Tisdall
Contact email
Sponsor organisation
Great Ormond Street for Children NHS Foundation Trust,
Clinicaltrials.gov Identifier
16HN21, Great Ormond Street Hospital - R&D Number
Duration of Study in the UK
1 years, 0 months, 0 days
Research summary
The aim of the SOLVe Trial is to understand how brain haemorrhage impacts on the brain. By analysing 'live-slice' samples taken intraoperatively from patients undergoing epilepsy surgery, the SOLVe trial has the potential to significantly add to our understanding of how bleeding impacts on the brain of children, specifically premature babies who are prone to brain bleeds.
During disconnection surgery for the treatment of medically intractable epilepsy, a trench is cut through the wall of the lateral ventricle and under normal circumstances this tissue would be discarded. Patients enrolled in the SOLVe trial will have this tissue repurposed such that rather than discarding it, it will be 'kept-alive' in artificial CSF thus allowing the research team to study how bleeding impacts on the wall of the lateral ventricle in 'real-time'.
A sample of CSF and blood will also be taken at the time of operation. By using blood and CSF derived from the patient we hope to limit the potential erroneous impact of using blood and CSF derived from other sources, this method of using autologous samples on live slice samples should create study conditions which accurately recreate the human condition.
This novel method of studying the wall of the lateral ventricle in 'real-time' will provide a unique insight into the complexities of how haemorrhage impacts on the developing brain and also has the potential to provide a platform to develop novel therapies to limit or prevent it.
REC name
London - Bromley Research Ethics Committee
REC reference
18/LO/1275
Date of REC Opinion
14 Sep 2018
REC opinion
Further Information Favourable Opinion