The ictal behaviour in NES with or without an abnormal EEG

• Research type

  Research Study

• Full title

  Is the Ictal behavior during non-epileptic seizures different between patients with interictal epileptiform discharges and patients without interictal epileptiform discharges?

• IRAS ID

  244736

• Contact name

  H Kargwell

• Contact email

  haga.kargwell@srft.nhs.uk

• Sponsor organisation

  salford royal NHS trust foundation

• Duration of Study in the UK

  1 years, 0 months, 0 days

• Research summary

  Introduction
  Patients, who have interictal epileptiform EEG abnormalities and have epileptic seizures that are fully controlled with medications, but have ongoing nonepileptic seizures that mimic epileptic seizures in behavior reported by witnesses of the seizure. Patients with tempotal spikes on EEG are likely to have experienced complex partial seizures. They may have experienced auras presceding complex partial seizures. They may have heard the description of their own behavior during the epileptic seizure or read it in the internet or being asked by physician with regard to occurrence of the typical symptoms. They may have nonepileptic attack seizure that has been shaped by these prior experiences or information.
  Among patients with nonepileptic seizures cerebral dysfunction and experiences might be reflected in various ictal behaviors of none epileptic seizure.
  
  Objectives
  Hypothesis: Is to see if the behavior of the nonepileptic attack seizures in patients with focal or generalized epileptiform discharges (IEDs) is similar to the behavior of complex or generalized epileptic seizures than those who don’t have IEDs on videotelemetry EEG.

  
  Methodology:
  It’s a retrospective study. All patients admitted during the period between May 2010 to May 2017 with Nonepileptic seizure or dual diagnosis will be enrolled. All these patients are already consented for their admission to the videotelemetry, risk factors, medication reduction, research, training, teaching and publications. The data will be collected by reviewing the videotelemetry EEG recording, the EEG and videotelemetry records s, neuropsychology records, medisec and sunrise. The videos and the EEG will be reviewed by two clinical neurophysiologists and possibly neuropsychologist .The neuropsychology records will be assessed by the neuropsychologists

  Data collection/analysis
  The data will be collected retrospectively.

• REC name

  North West - Liverpool Central Research Ethics Committee

• REC reference

  18/NW/0456

• Date of REC Opinion

  14 Jun 2018

• REC opinion

  Favourable Opinion