The First Failure Study

• Research type

  Research Study

• Full title

  A randomised, open label, prospective study to assess two different therapeutic strategies following first treatment failure in HIV-1 infected subjects. ‘The First Failure Study’ : ‘FAST’

• IRAS ID

  32453

• Contact name

  Alan Winston

• Eudract number

  2009-011816-39

• ISRCTN Number

  Not Submitted

• Research summary

  This is a 96 week clinical trial to assess two different combinations of antiretroviral drugs for the treatment of HIV when changing treatment at the time of the failure of the participants first antiretroviral regime.The participants will be randomised to receive either the standard of care treatment (Darunavir boosted by ritonavir plus Truvada) or a novel regime of darunavir boosted by ritonavir plus etravirine.There is a lumbar puncture sub study to describe the differences in darunavir cerebrospinaflud plasma concentration ratio between treatment arms

• REC name

  London - Hampstead Research Ethics Committee

• REC reference

  09/H0720/138

• Date of REC Opinion

  21 Jan 2010

• REC opinion

  Further Information Favourable Opinion