The EX-FRAIL CKD Trial
Research type
Research Study
Full title
The EX-FRAIL CKD Trial: a pilot mixed-methods randomised controlled trial of a home-based EXercise programme for pre-FRAIL and FRAIL, older adults with chronic kidney disease
IRAS ID
244772
Contact name
Andrew Nixon
Contact email
Sponsor organisation
Lancashire Teaching Hospitals NHS Foundation Trust
Duration of Study in the UK
1 years, 0 months, 19 days
Research summary
Frailty is common in people with chronic kidney disease. It is linked with disability, poorer quality of life and an increased risk of death. Despite knowing this, we do not know what is the best way to care for those that are frail with chronic kidney disease.
Studies have demonstrated that exercise appears helpful for frail older people. However, frail people with chronic kidney disease have health problems that are different to older people with normal kidneys. Muscle wasting appears to be more severe as kidney failure worsens. Exercise may decrease the muscle wasting that occurs and improve the overall health and quality of life of frail patients with chronic kidney disease.
Most research studies of exercise programmes are done under close supervision outside a person’s own home. They are difficult to set up as they are expensive and require a lot of time from busy staff. They may also be demanding for frail older people as they need to travel to take part in exercise. Research is needed to explore the benefits of a home-based exercise programme for frail older people with chronic kidney disease.
We propose a preliminary study to be conducted over 12-months that investigates whether it would be possible to perform a larger study that examines the benefits of a home-based exercise programme for frail older people with chronic kidney disease. We have received feedback on our study from members of a local kidney charity, a group of older patients with chronic kidney disease and members of the public. We have modified the study based upon this feedback.
If we can successfully perform this preliminary study and participants find the study acceptable, we will use the information gathered to design a larger study that examines the benefits of a home-based exercise programme for frail older people with chronic kidney disease.
REC name
North West - Greater Manchester East Research Ethics Committee
REC reference
18/NW/0211
Date of REC Opinion
14 May 2018
REC opinion
Further Information Favourable Opinion