The effects of mixed meals on gastric emptying and lipid metabolism
Research type
Research Study
Full title
The effects of changing the liquid/solid content of an isoenergetic test meal on gastric emptying and triglyceride rich lipoprotein metabolism
IRAS ID
155616
Contact name
Xuefei Li
Contact email
Sponsor organisation
MRC Human Nutrition Research
Duration of Study in the UK
3 years, 0 months, 0 days
Research summary
Gastric emptying (GE) is a complex physiological response to the presence of food, which is regulated by different factors including hormones, nervous system feedback control, and the properties of meals.
How different meal composition influences food uptake has great relevance to the causes of obesity, particularly in light of the recent debates about exposure to sugary drinks and other sources of free sugars. A previous study in our lab investigated the role of micronutrient compositions in GE and suggested that sufficient liquid form of carbohydrate in a mixed meal may delay GE independent of macronutrient composition. To test this hypothesis, we propose to conduct a similar 36-month study in which we will adjust the meals by exchanging the solid carbohydrate with liquid carbohydrate.
The primary aim of this study is to investigate whether the liquid, carbohydrate rich, component of a mixed meal delays gastric emptying of the solid portion of a mixed meal and what is the impact of these changes on the metabolism of postprandial triglyceride rich lipoprotein (TRL), including chylomicron and VLDL, using stable isotopic labelling technique.
The secondary aim of this study is to investigate the mechanisms underlying the meal-driven changes in intestinal physiology, with a particular respect to the effect induced by carbohydrates on the release of gut hormones (including cholecystokinin (CCK), glucagon-like peptide-1 (GLP-1), glucose-dependent insulinotropic polypeptide (GIP) and peptide YY (PYY)), the secretion of insulin and the regulation of postprandial glycaemia.
Twelve participants will take part in this randomised, 5-way crossover study. Breath tests will be used to assess GE. Five mixed meals with varying liquid/solid component ratios will be used.REC name
East of England - Cambridgeshire and Hertfordshire Research Ethics Committee
REC reference
15/EE/0232
Date of REC Opinion
3 Jul 2015
REC opinion
Further Information Favourable Opinion