The effects of insulin detemir in type 1 diabetes

• Research type

  Research Study

• Full title

  The effects of subcutaneous insulin detemir on glucose flux, pharmacokinetics and brain function in type one diabetes

• IRAS ID

  75008

• Contact name

  Roselle Herring

• Sponsor organisation

  University of Surrey

• Eudract number

  2011-001642-14

• ISRCTN Number

  n/a

• Research summary

  Why: Glucose is an essential nutrient to the human body and is a major energy source for many cells. . Blood glucose levels are maintained by insulin and glycogen. Insulin is released from beta cells in the pancreas and lowers blood glucose levels by causing the liver to convert glucose to glycogen, encouraging muscle and fat to take up glucose from the blood stream and enhancing the synthesis of fatty acids and proteins. The liver removes 60% of insulin and the remainder enters the blood supply to reach peripheral tissues. One of the current disadvantages of insulin substitution is that insulin is delivered into subcutaneous tissue and absorbed directly into the blood supply. The peripheral tissues are therefore exposed to relatively more insulin and the liver relatively less than under normal circumstances.What: We have designed two protocols to highlight the importance of the physiological action of insulin on the liver versus the periphery and to compare the effects on fuel production and brain function in patients with type 1 diabetes. Who: Patients with type 1 diabetes as they do not produce their own insulin. Where: Single centre study. (Cedar Centre. Royal Surrey County Hospital. Guildford)How: In protocol A insulin will be acutely withdrawn,blood glucose levels will be allowed to increase to 7 mmol/l . At this point an appropriate dose of subcutaneous insulin (detemir or NPH will be administered. The effects on liver glucose production, peripheral glucose uptake and peripheral lipolysis will be studied using modern stable isotopes. In Protocol B the effects of insulin detemir and NPH on fueflu and brain activity will be studied. Blood glucose levels will be stabilised at 5 and then 10 mmol/l. Electroencephalography will be used to study brain activity and modern stable isotopes to study fueflu. EudraCT - 2011-001642-11

• REC name

  London - Hampstead Research Ethics Committee

• REC reference

  11/LO/0687

• Date of REC Opinion

  11 Jul 2011

• REC opinion

  Further Information Favourable Opinion