The effects of exercise and/or antioxidants on outcomes in patients
Research type
Research Study
Full title
The effects of exercise and/or antioxidants on outcomes in patients undergoing surgery for colorectal cancer: a pilot prospective randomised trial
IRAS ID
128350
Contact name
John Hartley
Contact email
Sponsor organisation
Hull & East Yorkshire Hospitals NHS Trust
Research summary
This study aims to establish whether an individualised exercise programme prior to surgery can improve clinical outcomes in patients undergoing elective surgery for colorectal cancer. Traditionally patients remained in hospital for up to two weeks following major resection surgery however since the introduction of enhanced recovery after surgery protocols; different strategies to reduce the stress response during the procedure and enhance recovery after surgery have been studied. It is hoped therefore that this idea may be developed further through the use of exercise preconditioning. It is proposed that a short term exercise programme will further help prepare the patient both physically, physiologically and mentally to the stresses that surgery imposes on their bodies.
Participants eligible for the study will be those aged 18 or over, undergoing elective colonic resection at the Academic Surgical Unit, Castle Hill Hospital, Cottingham. Participants will be randomised into one of two groups: 1) Exercise intervention + standard care (intervention group) or 2) Standard care only (control group). All participants will be required to complete a series of functional capacity tests at the hospital upon entry to the study. These will aim to reflect everyday tasks such as rising from a chair and climbing stairs. Those randomised to the exercise intervention will be asked to complete an individualised exercise programme three times a week at the University of Hull under the supervision of a exercise physiologist. These will take place in the 2 to 4 week period between diagnosis and prior to surgery. It is expected the study will last between 18 and 24 months depending on the success of recruitment.
REC name
Yorkshire & The Humber - South Yorkshire Research Ethics Committee
REC reference
13/YH/0322
Date of REC Opinion
23 Oct 2013
REC opinion
Further Information Favourable Opinion