The effect of pre-exercise feeding on bone turnover biomarkers - V1
Research type
Research Study
Full title
The influence of pre-exercise feeding on acute bone turnover biomarkers in response to physical activity in healthy participants
IRAS ID
343204
Contact name
Jasmine Samvelyan
Contact email
Sponsor organisation
Sheffield Hallam University
Clinicaltrials.gov Identifier
Duration of Study in the UK
0 years, 5 months, 31 days
Research summary
Osteoporosis is a major contributor to loss of independence due to bone fractures and resulting hospital treatments lead to significant morbidity. While pharmacological treatments can reduce consequences of osteoporosis, there is a pressing need for non-pharmacological interventions to improve bone health across the life-course and to reduce likelihood of age-related bone disease.
This study will allow us to determine whether synergistic potentiating effects on bone metabolism are observed in humans in relation to the timing of food ingestion. If we can identify interventions that potentiate bone's response to aerobic exercise in younger adults, then such interventions may have the ability to maximise bone mass in younger adults so that with ageing, the additional bone mineral density and improved bone microarchitecture would extend the time before osteoporotic 'fracture thresholds' are reached.The study will be conducted at the Advanced Wellbeing Research Centre; AWRC (Sheffield Hallam University, UK). The study will conform to all standards of Good Clinical Practice and will be overseen by an experienced academics.
In this three-arm randomised crossover study, sixteen young adult men (age: 28 ± 4) will be recruited in good physical condition. Participants will be exercised following a 12-hour overnight fast (FAST) and exercised 90 minutes after a meal (FED) to test the temporal sensitivity of the loaded bone to absorbed nutrients. Participants will also attend a breakfast-only arm (without the exercise protocol).
Participants will undergo a baseline assessment for health history (PAR-Q). The blood samples will be collected (10ml) and osteogenic response to exercise will be determined by measuring markers of bone formation; PINP and resorption; CTX-1 and cortisol; marker of physiological and psychological stress. Insulin and glucose measurements will allow to assess the change of concentrations in fasted and fed states.REC name
Yorkshire & The Humber - Sheffield Research Ethics Committee
REC reference
24/YH/0213
Date of REC Opinion
20 Nov 2024
REC opinion
Further Information Favourable Opinion