The effect of hydration status on glycaemia and appetite_v1

• Research type

  Research Study

• Full title

  The effect of hydration status on glycaemic control and appetite regulation

• IRAS ID

  183737

• Contact name

  Harriet Carroll

• Contact email

  hac38@bath.ac.uk

• Sponsor organisation

  University of Bath

• Duration of Study in the UK

  2 years, 0 months, 0 days

• Research summary

  Does hydration status impact blood sugar control and appetite regulation in healthy adults? Understanding the mechanisms behind obesity and diabetes can aid in their prevention and potentially improve their management/treatment. The direct effects of everyday levels of dehydration on blood sugar control are currently unknown, which may have implications for improving diabetes diagnostics, management and prevention. Mild dehydration is common in the general public, thus understanding how this may affect appetite is important.

  Sixteen healthy adults (capable of providing informed consent) aged 18-60 years, with no known glucose disorders and not meeting any other criteria which may cause harm and/or introduce bias into the study will be allowed to participate.
  This study will be conducted at the University of Bath.

  This will be a randomised crossover trial. Days 1-3 will consist of monitoring (e.g. diet, hydration status). These will be matched on both arms of the trial. Day four involves the same measures, plus a peripheral quantitative computed tomography (pQCT) scan. Participants will be fluid restricted and will not be allowed caffeine or alcohol. In the afternoon, they will enter a heat tent in order to lose 1 % of their bodyweight in water (or maximum 60 minutes). They will be allowed low-water content foods. Those in the dehydration arm will be allowed to consume 3 mL/kg water; those in the rehydration arm will be allowed 40 mL/kg plus 150 % water losses, metered throughout the afternoon/evening. On day 5, the pQCT scan will be repeated, along with measures of hydration status and a muscle biopsy. A standard oral glucose tolerance test will be conducted and their blood flow and metabolic rate will be measured, followed by another muscle biopsy. Lastly, participants will have a filmed buffet and post-meal blood samples.

• REC name

  South West - Cornwall & Plymouth Research Ethics Committee

• REC reference

  16/SW/0002

• Date of REC Opinion

  1 Feb 2016

• REC opinion

  Unfavourable Opinion