The effect of exercise on hormones, inflammation and muscle damage;v1
Research type
Research Study
Full title
A clinical evaluation to profile the effects of time of day of exercise on anabolic and catabolic hormones, and other key metabolites, in healthy adult males (14-004)
IRAS ID
161721
Contact name
Frans van den Berg
Contact email
Sponsor organisation
GlaxoSmithKline Research and Development Ltd
Research summary
Regular exercise improves physical fitness, and promotes muscle growth and general good health. We think that’s partly because exercise affects levels of some types of hormone, and because it reduces inflammation and muscle damage.
Hormones are the human body’s messenger service – they carry messages in blood to and from different parts of the body. There are lots of different types of hormone, some of which affect recovery and growth of muscles. Many things affect the levels of those hormones, such as time of day, meal times, and muscle stress caused by exercise. So, understanding how exercise affects hormones is complicated.We’re doing this study in 18 healthy men, aged 18–35 years, who exercise regularly, to find out whether:
* body temperature, the levels of hormones that affect muscle growth and recovery, and markers of inflammation and muscle damage, differ, depending on the time of day, at rest and after exercise; and
* changes in levels of those hormones and markers are linked to changes in body temperature.We hope that answering those questions will help us to develop nutritional supplements to improve muscle recovery and growth in people who exercise regularly.
Participants will have 3 study sessions: they’ll rest in Session 1, and do exercise either in the morning or the evening in Sessions 2 and 3. They’ll take up to 7 weeks to finish the study, and have 1 outpatient visit and 3 inpatient stays (9 nights in total).
A pharmaceutical company (GlaxoSmithKline Research and Development Ltd) is funding the study.
The study will take place at 1 centre in London.
REC name
South Central - Hampshire B Research Ethics Committee
REC reference
14/SC/1237
Date of REC Opinion
15 Sep 2014
REC opinion
Further Information Favourable Opinion