The Ean NEuro-covid ReGistrY Consortium (ENERGY)
Research type
Research Study
Full title
The Ean NEuro-covid ReGistrY Consortium (ENERGY)
IRAS ID
285491
Contact name
Tom Jenkins
Contact email
Sponsor organisation
Sheffield Teaching Hospitals NHS Foundation Trust
Duration of Study in the UK
5 years, 0 months, 1 days
Research summary
An unexpected outbreak caused by COVID-19 virus is devastating the world population and the global economy. Europe is at present the continent with the highest number of affected individuals and deaths. Despite the exponential increase in the number of infections, information on the full spectrum of the disease is still insufficient. Recent reports strongly suggest that COVID-19 infection spreads to organs other than the respiratory system, including the central and peripheral nervous system. The involvement of the nervous system can be due to a direct action of the virus on the nervous tissue and/or to an indirect action through the activation of immune-mediated mechanisms. Moreover, the need for prolonged intensive care management in severe COVID-19 patients leads to well-known adverse effects on the central and peripheral nervous system, including post Intensive Care Unit (ICU) syndrome and ICU acquired weakness.
Currently available information can provide a picture of the rich spectrum of symptoms, signs, and diagnoses associated with COVID-19 infection. However, in light of the wide differences in timing and severity of the outbreak across Europe, it is impossible to define the association between the impairment of neurological functions and the outcome of infection. Consequently, to adopt adequate preventing measures without a systematic collection of the information in a well-defined cohort of patients is very challenging.Only a European registry can shed some light on the burden and general characteristics of neurological complications of the COVID-19 outbreak and the association of these complications with the demographic and clinical features of the affected individuals.
The main objective of this international Registry is to provide epidemiological data on neurological manifestations (symptoms/signs and diagnoses) in patients with COVID-19 infection reported by neurologists in outpatient services, emergency rooms, and hospital departments.
REC name
West Midlands - Edgbaston Research Ethics Committee
REC reference
21/WM/0036
Date of REC Opinion
1 Feb 2021
REC opinion
Favourable Opinion