The ChilSFree Trial

• Research type

  Research Study

• Full title

  Immunomonitoring after paediatric liver transplantation –in search of genetic and functional markers of over- or under-immunosuppression and a phamacogenetic evaluation of the impact of tacrolimus in children following liver transplantation\n\nA European multi-centre, open, prospective observational trial in children with steroid free immunosuppression following paediatric liver transplantation\n-The ChilSFree Trial-\n

• IRAS ID

  123169

• Contact name

  Patrick McKiernan

• Contact email

  pat.mckiernan@bch.nhs.uk

• Sponsor organisation

  R&D Department, Birmingham Children's Hospital

• Research summary

  Improved results in paediatric liver transplantation has shifted focus from clinical research to improving patient survival and quality of life. One of the major challenges is to optimise immunosuppression in order to reduce drug toxicity and infection whilst maintaining adequate immunosuppression preventing rejection, renal dysfunction and possible graft loss. One of the challenges is understanding how the immunosuppression interacts with the patient’s immune system. This study will look at immunological and genetic markers in each patient to determine how the immunosuppression is broken down \n

• REC name

  West Midlands - South Birmingham Research Ethics Committee

• REC reference

  13/WM/0369

• Date of REC Opinion

  7 Oct 2013

• REC opinion

  Further Information Favourable Opinion