The association of HPV and Prostate, Bladder and Renal cancers
Research type
Research Study
Full title
Association of human papillomavirus (HPV) and Urinary system cancers (Prostate, Bladder and Renal)
IRAS ID
204705
Contact name
Sarbjinder Sandhu
Contact email
Sponsor organisation
Kingston University Hospitals NHS Trust
Duration of Study in the UK
3 years, 0 months, 30 days
Research summary
Prostate cancer is one of the most common male malignancies worldwide. In most cases, the initiating factors remain unidentified. HPV is a well-known carcinogenic factor and vaccinations against certain HPV types have previously shown to reduce cervical cancer incidence rates in women. It is still not fully known whether HPV is present in prostate tissues or not. The identification of the presence of HPV will allow potentially improved prevention techniques for prostate cancer in men, and bladder and renal cancers in both genders.
This study will investigate the presence of human papillomavirus (HPV) in benign and malignant prostate, bladder and renal tissues, and correlate this with prognostic factors for these cancers. Participants will consent preoperatively to allow samples to be taken during surgery. The collection of benign (hyperplastic) and cancerous prostate, bladder, and renal tissues will be performed following removal of tissue at surgery or radiology via core biopsy. Samples will be link anonymised, so they remain unidentifiable at collection for transportation to Kingston University of London for the analysis in the School of Life sciences, Pharmacy and Chemistry in a tightly sealed container. Upon the completion of analysis samples will be completely destroyed. Only the consultant, who is a member of the clinical care team, will have access to patient information. Laboratory research staff will not have any access to patient information, so that the study remains blind to this group of researchers. Results on the presence of HPV will be analysed and relevant statistical analysis will be performed to establish a correlation of HPV and urinary system cancers.
REC name
East Midlands - Leicester Central Research Ethics Committee
REC reference
17/EM/0393
Date of REC Opinion
16 Nov 2017
REC opinion
Further Information Favourable Opinion