The ADENOMA Study
Research type
Research Study
Full title
The ADENOMA study - Accuracy of Detection using ENdocuff Optimisation of Mucosal Abnormalities
IRAS ID
156278
Contact name
Colin Rees
Contact email
Sponsor organisation
South Tyneside NHS Foundation Trust
Research summary
Bowel cancer is common in the UK, with around 1 in 16 men and 1 in 20 women developing it at some point in their lives. Most bowel cancers happen when a type of polyp (a growth in the bowel) called an adenoma becomes cancerous. Doctors use a camera test, known as a colonoscopy, to look inside the bowel and find these polyps and remove them. Removing pre-cancerous polyps is known to reduce the chances of a person developing bowel cancer in the future. How good colonoscopists are at finding these polyps varies, and there is a lot of research into how to improve “adenoma detection rates”.
A new device, called the Endocuff Vision (a small plastic device attached to the end of the colonoscope which helps by holding the folds of the bowel back to give a clear view of the inside of the bowel) has been shown to improve the rate of polyp detection at colonoscopy, and to make polyp removal easier. Previous small studies have shown that there is a significant improvement in detection of adenomas when an Endocuff Vision is used (with the rate of detection of adenomas rising from 49% to 66%). Colonoscopists who have used the Endocuff before also feel that polyp removal is easier when the Endocuff is on the colonoscope.
This study will randomise patients coming for colonoscopy to have their procedure performed as usual (i.e. without the Endocuff Vision attached) or as an Endocuff-assisted colonoscopy. We will record polyp and adenoma detection rates, duration of procedure, participant comfort levels, and complications. All patients referred for colonoscopy (via the symptomatic service, surveillance procedures, and the Bowel Cancer Screening Programme) will be invited in 7 centres (a mixture of specialist centres and district general hospitals), recruiting a total of 1772 participants.
REC name
North East - York Research Ethics Committee
REC reference
14/NE/1111
Date of REC Opinion
23 Sep 2014
REC opinion
Favourable Opinion