Testing bispecific antibodies using human tumour tissue on chip v2
Research type
Research Study
Full title
Testing the effects of bispecific antibodies targeting markers expressed by tumours and immune cells using human tumour tissue on chip
IRAS ID
263319
Contact name
John Greenman
Contact email
Sponsor organisation
University of Hull
Duration of Study in the UK
1 years, 11 months, 31 days
Research summary
The aim of the work is to test two novel antibody molecules made by F-star, a pharmaceutical company, against tissue biopsies taken from cancer patients and maintained alive in a microfluidic device. These novel antibodies have been engineered to effect the tumour and the immune cells, and studying their effects on human tissue will provide unique information about how they work. This is a preclinical laboratory investigation to study how the novel drugs (antibodies) work.
The use of the microfluidic devices (chips) allows human tissue to be studied rather than rely on animal models or tumour cell lines; neither of which fully represent the human situation.REC name
Yorkshire & The Humber - South Yorkshire Research Ethics Committee
REC reference
19/YH/0202
Date of REC Opinion
24 Jul 2019
REC opinion
Further Information Favourable Opinion