Targeted therapy for Charcot bones in diabetes (TORCH-D)

• Research type

  Research Study

• Full title

  Novel dual-action targeted therapy for improved healing of Charcot bones in diabetes

• IRAS ID

  331069

• Contact name

  Nina L Petrova

• Contact email

  nina.petrova@nhs.net

• Sponsor organisation

  King's College London

• Clinicaltrials.gov Identifier

  331069 , KCH Sponsorship Review Checklist

• Duration of Study in the UK

  1 years, 0 months, 1 days

• Research summary

  Trauma in people with diabetes and damaged nerves can lead to the Charcot foot in which overactive bone breaking cells cause bone damage and destruction. Despite prolonged protection in a cast, the foot becomes deformed. This may lead to lower limb amputation.
  Currently, no therapies prevent bone destruction. We propose to develop in the laboratory a bone-strengthening system to be applied at the site of bone damage. We will assess how to reduce the overactivity of bone breaking cells by testing different proteins attached to substances known as bioceramics.
  Such material will be used to deliver these proteins to repair injured bones and improve healing.

• REC name

  Yorkshire & The Humber - South Yorkshire Research Ethics Committee

• REC reference

  23/YH/0228

• Date of REC Opinion

  12 Oct 2023

• REC opinion

  Further Information Favourable Opinion