SYNCHRO

• Research type

  Research Study

• Full title

  Sleep Apnoea, Arrhythmias, and Cardiac Reverse Remodelling in Heart Failure patients

• IRAS ID

  213207

• Contact name

  Klaus WITTE

• Contact email

  k.k.witte@leeds.ac.uk

• Sponsor organisation

  LivaNova

• Clinicaltrials.gov Identifier

  NCT02870647

• Duration of Study in the UK

  3 years, 6 months, 30 days

• Research summary

  In a heart disease called Heart Failure the heart doesn’t pump as well as it should, and that can be treated by an implantable device. A small battery-powered device called CRT-P (Cardiac Resychronisation Therapy – Pacemaker) is placed under the skin near the collarbone in a minor surgical procedure. Three insulated wires called leads connect the device to the heart.

  Heart failure develops slowly as the heart muscle slowly weakens. The "failure" refers to the heart's inability to pump enough blood to meet the body's needs. Often times, in patients with heart failure, the lower chambers of the heart (ventricles) do not contract (pump) when they should, making it hard for the heart to pump blood efficiently.
  An implantable device can pace the lower chambers of the heart helping them contract or pump at the appropriate times, so that the heart pumps blood more efficiently. This therapy is called bi-ventricular pacing or cardiac (heart) resynchronisation therapy (CRT). This device can also pace the right atrium (the upper right chamber) of your heart, and is called CRT-P (Cardiac Resynchronisation Therapy Pacemaker)
  Moreover, patients that suffer from Heart Failure, are also frequently affected by atrial fibrillation (the upper part of the heart contracts too fast), and can also be affected by sleep breathing disorders (like nocturnal apnea, snoring, sleep related groaning). This is often under diagnosed.

  The aim of this study is to investigate the correlation between Heart Failure, severe Sleep Breathing Disorders and Atrial Fibrillation, in CRT-P patients.

• REC name

  East of England - Cambridge East Research Ethics Committee

• REC reference

  17/EE/0077

• Date of REC Opinion

  24 Feb 2017

• REC opinion

  Favourable Opinion