Surgical Interventions for Renal Stones
Research type
Research Study
Full title
The clinical and cost effectiveness of surgical interventions for stones in the lower kidney: The PUrE RCT- Percutaneous Nephrolithotomy (PNL), Flexible Ureterorenoscopy (FURS) and Extracorporeal Lithotripsy (ESWL) for lower pole Kidney stones.
IRAS ID
188563
Contact name
Samuel McClinton
Contact email
Sponsor organisation
Grampian Health Board
ISRCTN Number
ISRCTN98970319
Duration of Study in the UK
4 years, 11 months, 30 days
Research summary
Renal tract stone disease is very common and mainly affects adults of working age and the incidence has been increasing. Approximately 50% of renal stones will cause symptoms and up to 26 % will require an active intervention. Currently the NHS has three treatment options for lower pole kidney stones, extracorporeal shock wave lithotripsy (ESWL), percutaneous nephrolithotomy (PNL) and flexible ureterorenoscopy with laser lithotripsy (FURS). Current evidence indicates that these treatment options differ in efficacy, invasiveness, anaesthetic requirement, treatment setting, number of procedures and type and rate of complications.A cochrane review highlighted that there is limited robust evidence to inform the relative effectiveness and cost-effectiveness of ESWL, FURS and PNL in the treatment of lower pole kidney stones. This multi centre RCT (2 RCT in 1)(with internal feasibility) will determine for lower pole stones does flexible ureterorenoscopy with laser lithotripsy result in a better quality of life (EQ-5D) then ESWL or PNL (chosen according to stone size).
REC name
North of Scotland Research Ethics Committee 1
REC reference
15/NS/0113
Date of REC Opinion
10 Nov 2015
REC opinion
Further Information Favourable Opinion