Supported exercise training for men on ADT (STAMINA WORK PACKAGE 2)
Research type
Research Study
Full title
Supported exercise TrAining for Men wIth prostate caNcer on Androgen deprivation therapy (STAMINA) - Work Package 2 of the STAMINA programme.
IRAS ID
254343
Contact name
Derek Rosario
Contact email
Sponsor organisation
Sheffield Teaching Hospital NHS Foundation Trust
Duration of Study in the UK
5 years, 3 months, 0 days
Research summary
STAMINA is a NIHR PGfAR funded 5-year programme of research aimed at determining whether an exercise intervention, embedded in NHS cancer care, can be cost-effective and improve cancer-specific quality of life (QoL) for men with prostate cancer (PCa) on androgen deprivation therapy (ADT) when compared with usual care. This currently affects approximately 125,000 men annually, likely to increase to 200,000 and 300,000 in 2020 and 2030 respectively. ADT causes side-effects of hot flushes, fatigue, sexual problems and increases risks of dementia, diabetes and heart disease. Some ADT side-effects mimic recurrent cancer, leading to unnecessary consultations/tests. Supervised exercise is the only supportive treatment proven to improve disease-specific quality of life in these men. Short-term improvements have been demonstrated when delivered by specialist staff in non-NHS research centres, but these benefits dissipate without ongoing support. Finding cost-effective ways of getting men on ADT to take up and continue exercising is essential to reduce side-effects for sustained benefits.
We propose embedding an evidence-based, behaviourally-informed exercise programme into routine NHS prostate cancer treatment for men with prostate cancer on ADT This involves training cancer team members to endorse and support exercise, community-based gym professionals to deliver supervised exercise and communication between them to provide feedback and support. This model would offer an improved standard of care for men with prostate cancer and provide a blueprint for integration of exercise into other cancer services.In Work package 2, we shall develop and refine parallel, discipline-specific training packages for healthcare professionals and exercise professionals (based in community gym facilities) to endorse, prescribe, support and deliver individually-tailored, supervised weight-training and aerobic exercise programme.
Elements of work package 2 not requiring NHS ethics (e.g. developing training for exercise professionals) have been obtained through Sheffield Hallam University ethics.
Separate ethics applications for subsequent work packages will follow later in the programme timeline.
REC name
North West - Liverpool Central Research Ethics Committee
REC reference
18/NW/0738
Date of REC Opinion
22 Oct 2018
REC opinion
Favourable Opinion