SUPERSTARCH Version 1.0
Research type
Research Study
Full title
EFFECT OF A MODIFIED STARCH COMPARED TO STANDARD MALTODEXTRIN ON POST-OPERATIVE INSULIN RESISTANCE WHEN GIVEN PRE-OPERATIVELY FOR LAPAROSCOPIC COLORECTAL SURGERY AS PART OF AN ENHANCED RECOVERY PROGRAM.
IRAS ID
180508
Contact name
Anton Krige
Contact email
Duration of Study in the UK
0 years, 6 months, 23 days
Research summary
The aim of this study is to test the effect of giving patients who are having a laparoscopic bowel resection a modified, long acting starch drink (Generation UCAN) pre-operatively in comparison to the current glucose based drink (PreLoad®). The research team will be looking at the effect on post-operative resistance to insulin and on the stress response to surgery, looking for a reduction in both.
The development of insulin resistance post-operatively is a well-documented phenomenon, and is associated with an increase in morbidity and mortality following surgery. It has been shown that providing carbohydrates pre-operatively can attenuate the development of insulin resistance. The provision of a carbohydrate drink 2 hours pre-operatively has not been shown to affect the residual volume in the stomach at the time of surgery, with no additional risk of aspirating stomach contents at the start of anaesthesia.
The provision of a carbohydrate drink the night before and on the morning of surgery is well established as part of an Enhanced Recovery Programme in all UK hospitals and the patients within this trial will receive the rest of their care in accordance with these guidelines, the only alteration being the carbohydrate formulation they will receive pre-operatively.
Blood samples will be taken pre-operatively and on days 1, 2 and 3 post-operatively to assess the stress response and to measure the difference in the magnitude of change in insulin resistance in the first 3 days after surgery. The research team will also measure the residual gastric volume suing ultrasound immediately after general anaesthesia, compare the recovery profile following surgery between groups which will include the presence of post-operative nausea and vomiting, post-operative fatigue and the sensation of thirst & hunger post-operatively as well as difference in recovery of muscle strength.REC name
North West - Preston Research Ethics Committee
REC reference
15/NW/0511
Date of REC Opinion
30 Jun 2015
REC opinion
Favourable Opinion