Super resolution imaging for peripheral artery disease
Research type
Research Study
Full title
Super-resolution imaging versus reference imaging in people undergoing surgical revascularisation for chronic limb-threatening ischemia (CLTI).
IRAS ID
339383
Contact name
Amy E Harwood
Contact email
Sponsor organisation
Manchester Metropolitan University
Duration of Study in the UK
1 years, 0 months, 1 days
Research summary
Background: Over 236 million people worldwide have blocked leg arteries, a problem called peripheral artery disease. Of those, 25 million will develop more severe disease known as chronic limb threatening ischemia. This causes resting leg pain and can lead to ulcers, gangrene and tissue loss. Once people developed chronic limb threatening ischemia, they will need an operation on their leg arteries to restore the blood flow to the leg.
Sometimes this operation will not work, and people have to have more operations or end up losing their leg. Part of the problem in treating such a condition relates to the current inability of medical imaging technology to show the blood circulation in small vessels accurately and in detail.
Objectives: We have developed a new image analysis method called super-resolution ultrasound imaging (SRUI) that can tackle this problem. The objective of this project is to use see if our new imaging is able to be used and compare it to current imaging methods.
Methods: We will recruit about 15 people with chronic limb threatening ischemia to and compare standard imaging to our new imaging. We will also use clinical data from patient records. We will look to see if we can also predict which patients’ operations might not work.
We will share our results using lay summaries. We will also present our findings at conferences such as the Vascular Society of Great Britain and Ireland Annual Scientific Meeting and publish our results in a relevant journal such as Vascular Medicine.
REC name
West of Scotland REC 1
REC reference
24/WS/0083
Date of REC Opinion
26 Jul 2024
REC opinion
Further Information Favourable Opinion