Subclavian ansae stimulation in AF

• Research type

  Research Study

• Full title

  Effects of selective left subclavian ansae stimulation on human cardiac electrophysiological properties - a potential percutaneous target for neuromodulation in Atrial Fibrillation.

• IRAS ID

  303347

• Contact name

  Malcolm Finlay

• Contact email

  malcolm.finlay1@nhs.net

• Sponsor organisation

  Barts Health NHS Trust

• Clinicaltrials.gov Identifier

  NCT05133414

• Duration of Study in the UK

  1 years, 0 months, 1 days

• Research summary

  Atrial Fibrillation (AF) is the most common heart rhythm abnormality affecting approximately 3% of the population and treatment for AF.

  Although many advances have been made, there remains a pressing need to improve the treatment of AF.
  There is increasing recognition that the brain and nerve can influence the electrical activity of the heart. We aim to stimulate a specific set of nerves (specialised nerve that supply to the heart) that can affect the electrical activity of the heart and the results of the study may allow us to improve treatments for patients in the future by changing the function of this nerve, thus modifying the AF disease process.

  As this nerve lies very close to the artery that runs to the arm (called left subclavian artery) it will not be challenging to approach around this special nerve area through the artery. This can be easily accessed via the artery from groin putting a small tube under local anaesthetic.

  The primary aim of this study is to understand the effects in heart electrics as a result of stimulating this nerve. If so to determine the current energy that we need to deliver to stimulate this nerve safely and selectively.
  
  The study participants include patients who are referred for first time AF ablation at Barts Heart Centre, who are able to consent and age between 18-80 years old. Study will include 30 patients in total who will be eligible as per above criteria. Apart from the standard of care which is AF ablation, the study participants will be consented for additional artery access at groin and an additional procedure time of 30 minutes for the stimulation study under general anaesthesia. There are no study related follow up that is required for the participants apart from standard of care.

• REC name

  London - Surrey Research Ethics Committee

• REC reference

  22/LO/0084

• Date of REC Opinion

  13 Apr 2022

• REC opinion

  Further Information Favourable Opinion