Studying Antibiotic resistance in lung disease

  • Research type

    Research Study

  • Full title

    Tracking Antimicrobial Resistance in respiratory DISease (TARDIS)

  • IRAS ID

    199001

  • Contact name

    James Chalmers

  • Contact email

    jchalmers@dundee.ac.uk

  • Sponsor organisation

    Tayside Medical Sciences Centre/NHS Tayside

  • Duration of Study in the UK

    3 years, 0 months, 1 days

  • Research summary

    Antibiotic resistance (AMR) is a growing threat to public health and is common in respiratory tract infections. Patients with chronic respiratory infections such as COPD, asthma, bronchiectasis and cystic fibrosis receive frequent causes of antibiotics and are therefore at high risk of antibiotic resistance.

    The aim of this study is to determine what drives the development of antibiotic resistance in patients with chronic lung diseases.
    This is an observational cohort study in which patients with chronic lung conditions that are frequently treated with antibiotics will be recruited and data collected from their lung bacteria and from their electronic medical records with the following objectives: 1- to identify which patients have antibiotic resistant bacteria in their lungs, 2- to determine from electronic health records whether certain antibiotic behaviours e.g frequent courses of antibiotics, short or longer courses or rotating of antibiotics are associated with development of AMR. 3- to look at whether any specific personal factors like severity of lung disease or other medications contribute to AMR.
    Statisticians will use of this complex information with the goal of identifying and predicting which patients are at risk of AMR.

  • REC name

    North West - Greater Manchester West Research Ethics Committee

  • REC reference

    16/NW/0101

  • Date of REC Opinion

    5 Feb 2016

  • REC opinion

    Favourable Opinion