Study of natural antibodies for cardiovascular risk
Research type
Research Study
Full title
Optimization and evaluation of natural antibodies for Apo-B, LOX-1, VEGFR1 and VEGFR2 antibodies as predictors of cardiovascular risk
IRAS ID
236781
Contact name
Stephen Leslie
Contact email
Sponsor organisation
NHS Highland
Duration of Study in the UK
3 years, 0 months, 0 days
Research summary
This is a pilot study that will recruit 100 patients with acute coronary syndrome (ACS) mainly caused by arterial atherosclerosis, and 100 healthy controls to study natural antibodies for vascular growth factor receptors (VEGFRs), lectin-like oxidized low-density lipoprotein receptor 1 (LOX-1) and apolipoprotein B100 (ApoB). The aim of the proposed work is to explore the possibility of developing a clinical test for stratification of coronary artery disease risk. The following hypotheses will be tested: (1) whether natural antibodies against VEGFRs, ApoB and LOX-1 have a protective role in reducing risk of atherosclerosis; (2) whether plasma anti-VEGFR1, anti-VEGFR2, anti-ApoB and anti-LOX-1 IgG antibodies can serve as biomarkers for prediction of cardiovascular disease and heart event; (3)whether the polymorphisms of ApoB, LOX-1, VEGFR1 and VEGFR2 genes are associated with circulating levels of natural antibodies for the peptide antigens derived from the above four proteins.
All the participants will be given a pack containing the invitation letter, study questionnaire and participant information sheet. Potential participants will be allowed adequate time to decide whether or not to take part in the study. The PI, Prof Leslie or a member of his clinical team, will identify patients with ACS, and collect their clinical information; either a delegated nurse or Dr Mustard who is holding a Research Passport, will take consent. A PhD student will perform analysis of these blood samples as part of the PhD research project. All experimental results will be entered into a separate research database using only the numerical identity code. The research database will require passwords to access, and will be stored on password protected computers. Print out or CD containing research information will be kept in locked filing cabinets.
REC name
East Midlands - Derby Research Ethics Committee
REC reference
18/EM/0010
Date of REC Opinion
5 Jan 2018
REC opinion
Favourable Opinion