Study of induction of cell cycle arrest following chemotherapy
Research type
Research Study
Full title
The study of biomarkers of cell cycle arrest and DNA damage in blood and hair follicles following chemotherapy
IRAS ID
134315
Contact name
Udai Banerji
Contact email
Sponsor organisation
The Institute of Cancer Research
Research summary
his research is directed in understanding how the human body reacts following chemotherapy. The research uses samples of blood and hair before and after chemotherapy to study how the chemotherapy works. This information is critical to developing new drugs that potentiate or improve the effectiveness of current anticancer drugs.
Patients with cancer often have chemotherapy in order to cause damage to the cancer cells and stop cancer cell growth. However some cancer cells are able to temporarily stop their growth in order to repair the damage and continue growing later. It is important to study this mechanism in order to use the drugs that can impair the ability of cancer cells to temporarily stop and repair themselves effectively. This will help doctors to design more effective strategy when trying to design future clinical trials. During chemotherapy, anticancer drugs distribute in many body tissues including blood cells and hair follicles. It is possible to measure certain proteins in blood cells and hair follicles in order to study the effect of chemotherapy on normal cells and the mechanism by which the growth of cells is temporarily halted. The data from this study can be used to advance our knowledge about the cancer cells in response to chemotherapy.
REC name
London - Chelsea Research Ethics Committee
REC reference
14/LO/0301
Date of REC Opinion
16 Apr 2014
REC opinion
Further Information Favourable Opinion