Study of cell function and gene expression in human cells and tissue
Research type
Research Study
Full title
Assessment of gene expression and cell function in human tissue and peripheral blood to aid target validation and disease positioning studies in oncology research
IRAS ID
246390
Contact name
Stuart Farrow
Contact email
Sponsor organisation
CRUK-TDL
Duration of Study in the UK
4 years, 11 months, 30 days
Research summary
CRUK-TDL are developing novel drugs for cancer therapy. Access to human cells and tissue will help us to investigate the potential of these drugs, and to determine which cancers may be suitable for treatment with them.
For example, there is a need to understand where the targets of the experimental drugs, and other related molecules, are found in both tumour and healthy human tissues. In addition, the function of certain cells from the tissue can be assessed in the laboratory to further our understanding of the biology underlying the planned therapy.
In recent years, the therapeutic potential of modulating the immune system in the treatment of cancer has been recognized and we are investigating novel approaches in this area. The ability to perform experiments on human immune cells, for example isolated from peripheral blood, will help us to progress this work.
We intend to access samples of human tumours, healthy tissues and peripheral blood which have been obtained by academic collaborators, commercial suppliers or the NHS-BT. The samples will be entirely anonymous so that the donors will not be identifiable to us.
REC name
East of England - Cambridge Central Research Ethics Committee
REC reference
18/EE/0366
Date of REC Opinion
2 Nov 2018
REC opinion
Unfavourable Opinion