Studies on isolated skin samples to investigate new medicines
Research type
Research Study
Full title
Studies on isolated skin samples to investigate new medicines for the treatment of skin disorders
IRAS ID
121227
Contact name
David Bunton
Contact email
Sponsor organisation
ReproCELL-Europe Ltd
Research summary
Summary of results
Laboratory models used in the preclinical testing of drugs often fail to predict patient responses. This is partly due to the use of animal or cellular models that do not reflect the diversity of the human population or the condition. Fresh human tissues provide an excellent alternative screening option and do reflect this diversity making them a better predictor of drug response. The aim of this project was to investigate the treatment potential of new drugs to treat various skin conditions, such as, atopic dermatitis (AD) and psoriasis (PSo), using a fresh human skin laboratory system. These investigations were performed on behalf of companies who wished to test their new drug compounds in fresh human tissue based laboratory assays. During the course of the project research participants - healthy or diagnosed with AD or PSo donated small sections of affected or unaffected skin (biopsies).Those diagnosed with AD or PSo donated small sections of affected or unaffected skin (biopsies). These biopsies were used in the laboratory assay to test a total of 15 newly developed drug compounds. The data obtained from the assay provided information on how the drug worked (mechanism) and if there was an effective response for the condition (efficacy). The data from these tests has since been used to define further development of the tested compounds and to help refine the next clinical test phases.
REC name
West of Scotland REC 4
REC reference
13/WS/0052
Date of REC Opinion
11 Apr 2013
REC opinion
Further Information Favourable Opinion