Stryker ASSIST Registry

• Research type

  Research Study

• Full title

  Stryker ASSIST Registry

• IRAS ID

  263653

• Contact name

  Soumaya Mechaï

• Contact email

  soumaya.mechai@stryker.com

• Sponsor organisation

  Stryker - Neurovascular Devision

• Clinicaltrials.gov Identifier

  NCT03845491

• Duration of Study in the UK

  2 years, 8 months, 31 days

• Research summary

  Summary of Research
  stroke is the leading cause of death for people above the age of 60 and the fifth leading cause in people aged 15-59, and is the most common cause of chronic adult disability.According to the World Health Organization, approximately 15 million people suffer a stroke annually, about 5 million die, and another 5 million are permanently disabled as a result.
  Over the course of the past few years, treatment for stroke has rapidly evolved with the current recommendations including both intravenous Thrombolysis (drug treatment to 'disolve'the clot) and thrombectomy (physical clot removal) for select patients, based on positive outcomes shown in the five pivotal trials presented in 2014-2015. it was published to show the additional benefit of endovascular thrombectomy in decreasing disability for patients with large vessel anterior circulation ischemic stroke evidence also supports that reduced time from symptom onset to reperfusion with better clinical outcomes

  This is a single arm, open, multi-centre, prospective observational study collecting data to evaluate the safety and effectiveness of using the Stryker retriever or aspiration devices when used in a clinically indicated Thrombectomty procedure for Ischemic stroke.

  Summary of Results
  The ASSIST Registry collected real-world data on the safety and effectiveness of different mechanical thrombectomy techniques in acute ischemic stroke (AIS) patients. The registry collected clinical and procedural outcomes on 1492 subjects and stratified the data according to three main technique groups, Stent Retriever Classic (SR Classic), SR Combination, and Direct Aspiration.
  The results of the study reinforce the known benefits of mechanical thrombectomy within AIS patients. mRS at 90 days and the effectiveness of revascularization across the three technique groups are comparable to previously published data.

• REC name

  London - South East Research Ethics Committee

• REC reference

  19/LO/1363

• Date of REC Opinion

  19 Nov 2019

• REC opinion

  Further Information Favourable Opinion