STRIPE trial
Research type
Research Study
Full title
The STRIPE trial (Stimulation of the Tibial nerve Repetitively to Improve Incontinence in Parkinson's Electronically): a randomised control trial of tibial nerve stimulation in Parkinson's disease
IRAS ID
295856
Contact name
Matthew Smith
Contact email
Sponsor organisation
University of Bristol
ISRCTN Number
ISRCTN11484954
Duration of Study in the UK
2 years, 5 months, 27 days
Research summary
Bladder problems are a common occurrence for people with Parkinson's disease, affecting 50%. These include problems accidentally passing urine, getting up at night frequently to urinate and is made more difficult because of the problems they have with movement. Despite being common, bladder problems can be difficult to treat and people with Parkinson’s often have troublesome side effects with the main medications used. New treatments are therefore needed for this condition and has been highlighted as a priority for people with Parkinson’s.
Our research is a trial of a device that delivers a small electrical charge to the ankle. Previous work has shown this may be useful in treating people’s bladder symptoms and we aim to use a self-contained, easy to use device which will be helpful for people with Parkinson’s. People with bladder symptoms will be recruited from two sources. Firstly from the “PRIME-PD” research project run by our group in which many patients were asked about bladder symptoms. The second is from referral from other Parkinson’s doctors who have identified that their patient has bladder symptoms. Active stimulation of the ankle will be compared to a non-active form of stimulation to help us fully determine if this treatment works. The device needs to be worn twice per week for 30 minutes, for 12 weeks and the majority of these sessions can be delivered by the participants themselves at home. We aim to use questionnaire tests taken at regular time-points, participant bladder diaries and further bedside bladder tests to work out if there was an improvement with this treatment.
REC name
London - Camden & Kings Cross Research Ethics Committee
REC reference
21/LO/0418
Date of REC Opinion
24 Jun 2021
REC opinion
Further Information Favourable Opinion