Store-operated calcium entry in the human sweat gland version 1
Research type
Research Study
Full title
The invesigation of store-operated calcium entry in the human sweat gland
IRAS ID
190738
Contact name
Patricia Martin
Contact email
Sponsor organisation
Glasgow Caledonian University
Duration of Study in the UK
3 years, 0 months, 1 days
Research summary
In humans, the sweating process begins with a rise in body temperature, this signals the release of acetylcholine (ACh), which binds to and activates receptors and initiates the production of the signalling molecule inosotil triphosphate (IP3). IP3 subsequently stimulates a calcium pathway. The first stage is well known and calcium is released from within the cell. This calcium reduction is sensed within the cell and calcium then re-enters, this is know as store-operated calcium entry (SOCE). However, the re-entry of calcium into the cell is not so well understood. Over the past few years a number of key proteins have been recognised to be involved in the pathway and have been investigated in a number of different tissues. These proteins include ORAI which acts as a pore for calcium to re-enter the cell, and STIM which detects when calcium levels are low and signals ORAI to allow calcium entry. The role of these key proteins have not to date been investigated in sweat glands.
REC name
North West - Greater Manchester South Research Ethics Committee
REC reference
16/NW/0407
Date of REC Opinion
8 Jun 2016
REC opinion
Further Information Favourable Opinion