Statistical methods for population-based cancer data
Research type
Research Study
Full title
Development and application of statistical methods to maximize the increased opportunities made available in the UK with more detailed population-based cancer data
IRAS ID
160812
Contact name
Paul C Lambert
Contact email
Duration of Study in the UK
2 years, 11 months, 30 days
Research summary
Research Summary
The main aim of this application is to further develop statistical methods to optimise the use of population-based cancer data. In particular, to take advantage of the increased opportunities associated with recent improvements in the quality and quantity of UK cancer data. The project combines methodological development with application of the new methods in applied research using English population-based cancer survival data. Three specific aims are as follows.
1. Further develop methods to partition cancer related mortality into that due to cancer and that due to treatment related mortality, with application to Hodgkin lymphoma and breast cancer.
2. Develop computationally efficient methods for competing risks data when one event is of primary interest. Apply the methods to modelling the time to hepatic resection for colorectal cancer in the presence of competing risks.
3. Further develop methods for estimating the loss in expectation of life associated with a diagnosis of cancer with the aim of decomposition into different causes.The study will not be collecting new data, but will use routine NHS data available in the National Cancer Data Repository (NCDR).
Summary of Results
The aim of this project was to further develop statistical methods to optimise the use of population based cancer data. The project combined methodological development with application of the new methods in applied research using English population based cancer survival data.Work associated with this project led to around 15 publications, with 9 of them being methodological and the remainder applied projects. We also developed software to enable other researchers to implement the methods.
REC name
North West - Greater Manchester East Research Ethics Committee
REC reference
14/NW/1449
Date of REC Opinion
24 Nov 2014
REC opinion
Favourable Opinion