Spinal anaesthesia versus rectus sheath block for donor nephrectomy

• Research type

  Research Study

• Full title

  Does adding spinal anaesthesia to a general anaesthetic technique influence readiness for discharge in patients having hand assisted laparoscopic live donor nephrectomy - A randomised controlled trial

• IRAS ID

  181838

• Contact name

  Kailash Bhatia

• Contact email

  kailash.bhatia@cmft.nhs.uk

• Sponsor organisation

  Central Manchester University Hospitals R and D department

• Duration of Study in the UK

  2 years, 0 months, 1 days

• Research summary

  About 1100 living donor nephrectomies (removal of healthy kidney for transplant) are performed in the UK every year contributing to almost 35% of all the kidney transplants.Laparoscopic (key hole) surgical techniques are general employed for donor nephrectomy as they are associated with a shorter hospital stay and faster return to normal physical functioning. Spinal anaesthesia (injection in a patients spine that numbs the legs and abdomen) in combination with a general anaesthetic is increasingly being used as part of enhanced recovery programme across surgery. How this technique influences pain after surgery and readiness for discharge from hospital has not been studied in patients undergoing laparoscopic donor nephrectomy.

  We plan to investigate two commonly used anaesthesia techniques in 90 patients who will be undergoing donor nephrectomy surgery at Central Manchester University Hospitals NHS Trust over a period of two years. The patients will be divided in two groups of 45 each randomly and receive any one of the anaesthetic technique described. The first technique will involve giving a spinal anaesthetic followed by a general anaesthetic. The second technique involves a general anaesthetic in combination with an injection in the abdomen done during the surgery called rectus sheath block that potentially numbs the nerves of the abdomen.
  We will assess which technique could potentially be associated with a shorter hospital stay. We will also assess with each technique:
  i) Pain scores at 3 hours, 6 hours, 12hours and 24 hours after surgery
  ii) The total amount of oxycodone (morphine like pain killer) consumed by patients post- operatively via patient controlled analgesia (PCA - A pump used by patient to self inject medications for pain relief)
  iii) Side effects of the anaesthetic
  iv) Patient satisfaction

• REC name

  North West - Greater Manchester East Research Ethics Committee

• REC reference

  15/NW/0872

• Date of REC Opinion

  26 Nov 2015

• REC opinion

  Favourable Opinion