SPECKLE ECMO
Research type
Research Study
Full title
Evaluation of speckle tracking parameters as predictors of successful VA ECMO weaning procedure. A prospective observational pilot study.
IRAS ID
241001
Contact name
Susanna Price
Contact email
Sponsor organisation
Royal Brompton and Harefield NHS Foundation Trust (RB&HFT)
Duration of Study in the UK
1 years, 2 months, 0 days
Research summary
This project is non-commercial study which aims for assessing wheter measurements obtained through speckle tracking (Left Ventricle (LV) longitudinal and circumferential strain, Right Ventricle (RV) longitudinal strain) can give additional information to conventional echocardiograhic parameters (left ventricular outflow tract (LVOT) velocity time integral (VTI) increase, etc.) in identifying patients who develop adverse outcomes 30 days post successfully weaning from VA ECMO (liberation not for palliation). It is a prospective observational non-blinded pilot study. It will be assessed whether the population experiencing the outcomes of interest (death within 30 days from VA ECMO liberation, hospital admission for a new episode of cardiogenic shock or heart failure within 30 days from VA ECMO liberation, need for new mechanical circulatory support within 30 days from VA ECMO liberation) and the population not experiencing these outcomes have different values of strain (LV longitudinal, LV circumferential and RV longitudinal strain) during the weaning study.
VA ECMO can hemodynamically support patients in refractory cardiogenic shock due to medical, postcardiotomy, or post-cardiac arrest. VA ECMO can be used as a bridge to cardiac transplantation, to a long-term ventricular assist device (VAD), or until recovery of myocardial function. Weaning success from VA ECMO is defined as device removal and no further requirement for mechanical support. Management of VA ECMO weaning is difficult, and to date, no clinical or echocardiographic study has specifically evaluated predictors of the success of weaning. At present, the weaning strategies are based on Doppler VTI and ejection fraction (EF). According to the results of previous research, only 41% of patients who were successfully liberated from VA ECMO were subsequently discharged alive, with the majority of these patients dying in hospital. Heart failure and multiple organ failure were the principal causes of death in this study.REC name
London - Harrow Research Ethics Committee
REC reference
18/LO/0946
Date of REC Opinion
19 Oct 2018
REC opinion
Further Information Favourable Opinion