Southall And Brent REvisited (SABRE) - SABRE V3
Research type
Research Study
Full title
Consequences of ethnic differences in cardiometabolic disease in older age: the Southall And Brent REvisited (SABRE) tri-ethnic population cohort - SABRE V3
IRAS ID
140763
Contact name
Nish Chaturvedi
Contact email
Sponsor organisation
University College London
Research summary
By the age of 80, around half of South Asians and African Caribbeans, and a fifth of Europeans in the UK have diabetes. This has important consequences for an ageing population, increasing the risks of cardiovascular disease and cognitive disorders. These ethnic minorities appear more susceptible to the adverse effects of diabetes, although we do not understand the reasons for this. The Southall And Brent REvisited (SABRE) population-based cohort recruited middle-aged South Asian and African Caribbean migrants and a comparable European population between 1988 and 1991 (then aged between 40 and 70), with a 20 year follow up between 2008 and 2011. This new 25 year follow-up(SABRE-V3) of participants into older age will explore the ethnic differences in the metabolic disturbances associated with diabetes in order to gain understanding of heart failure/exercise intolerance and cognitive decline, together with the persistence of ethnic differences in cardiovascular disease. The study will also give insights into healthy ageing in the three ethnic groups.\n As at the 20 year follow-up, we will give participants the opportunity to take part in a number of ways: they may complete a questionnaire about their health and lifestyle, they may allow us to obtain information about the health from health-related records and/or they may attend our clinic at University College London to undergo blood tests and non-invasive measurements of both clinical and sub-clinical disorders of metabolism, the heart and circulation, and the brain and cognitive function. We will also invite partners of existing participants and a new group of African Caribbean participants to join the study in order to increase the ability of the study to achieve these aims. [COVID-19 amendment 06/05/2020] Southall And Brent Revisited (SABRE) is an established, London based, population representative tri-ethnic (South Asians, African Caribbeans and Europeans) older age cohort. It is uniquely placed to determine whether certain ethnic minority groups are at greater risk of Covid-19 infection and disease severity, and to understand the role of key explanatory factors in accounting for such ethnic differences.\n- We propose urgent field work in the form of home visits, and up to weekly telephone calls until the pandemic is established in London.\n- We will incorporate offer testing and clinical advice using protocols in place in related settings.\n- Principal scientific value is in understanding if there are ethnic differences in occurrence of Covid-19 symptoms and/or disease severity\n- It complements the work of DELPHIC (an out-patient cohort; REC ref: 16/LO/1217; IRAS: 164446) but adds vital *context* on the excess Covid-19 risk in ethnic minority groups.
REC name
London - Fulham Research Ethics Committee
REC reference
14/LO/0108
Date of REC Opinion
21 Feb 2014
REC opinion
Favourable Opinion