SouTh AsiaN DiaBetes remission feasibility studY (STANDby)
Research type
Research Study
Full title
Remission of Type 2 Diabetes (T2DM) in South Asians using a low energy formula diet: a feasibility study.
IRAS ID
212012
Contact name
Michael Lean
Contact email
Sponsor organisation
NHS Greater Glasgow and Clyde
Duration of Study in the UK
1 years, 0 months, 30 days
Research summary
Age, genetics and being overweight or obese are the three key contributory factors to the development of T2DM. Unlike age and genetic factors, people can affect their weight. Consensus now exists around weight loss in the region of 15kg (2-3stones) resulting in diabetes remission in a significant proportion of individuals with T2DM. Around 1% of the Scottish population is of South Asian ethnicity. South Asians are at higher risk of T2DM, developing the condition at a lower body weight than non-South Asians. This coupled with evidence that South Asians are less likely to access weight management services than non-South Asians points to a need for novel approaches to manage this growing problem. In the absence of appropriate management and support, the Scottish South Asian population would be at risk of developing health inequalities as well as the resulting health and health economic burden of sub optimal management of T2DM. A programme initially focusing on a low energy liquid formula diet is showing promising results both in terms of acceptability, weight change and impact on HbA1c. The formula food provides all essential nutrients in around 850kcal hence guarantees energy deficit and therefore weight loss with compliance. Many people appreciate the opportunity for a complete ‘step away from food’ and compliance is highly encouraging as compared with other weight management approaches due to the weight loss magnitude and associated clinical benefits such as reduction in fasting blood glucose and withdrawal of medications from as early as week one. The proposed study will examine if the initial phase of this approach using formula food products is acceptable to the South Asian population and if it results in similar clinical outcomes in terms of weight loss and diabetic status at the end of the formula diet, weight loss phase.
REC name
West of Scotland REC 3
REC reference
17/WS/0104
Date of REC Opinion
7 Jun 2017
REC opinion
Further Information Favourable Opinion