Somatic mutations in diverse cell types that constitute the skin
Research type
Research Study
Full title
Somatic mutations in diverse cell types that constitute the skin
IRAS ID
333260
Contact name
Yoshihiro Ishida
Contact email
Sponsor organisation
Genome Research Limited operating as The Wellcome Sanger Institute
Duration of Study in the UK
1 years, 11 months, 31 days
Research summary
This study aims to analyse somatic mutations in diverse cell types that make up the skin. Somatic cells make up all of the body’s cells, other than the cells involved in reproduction and this study aims to address several key issues relating to skin ageing and chronic inflammation.
We will analyses normal skin, as well as skin under chronic inflammation such as psoriasis and atopic dermatitis.
In normal skin, we aim to address somatic mutations in endothelial cells (cells that make up the blood wall) and fibroblasts (cells responsible for the maintenance of the skin structure) and correlate them with the gross phenotypes (the set of observable characteristics) of skin ageing.
In skin with chronic inflammation, we will investigate whether there is clonal expansion of lymphocytes and what role if any this may play in disease maintenance particularly if it could be ancestral to T-cell lymphoma.
In general terms this study will deepen our understanding of skin ageing and may provide therapeutic targets that may delay or reverse ageing. We also may provide novel therapeutic targets for chronic skin inflammatory disease which may provide prevention / proactive strategies to reduce/avoid lymphoma development.
REC name
West of Scotland REC 4
REC reference
23/WS/0149
Date of REC Opinion
26 Sep 2023
REC opinion
Favourable Opinion