SOFIA

• Research type

  Research Study

• Full title

  Subclinical Ochronosis Features on Alkaptonuria (SOFIA)

• IRAS ID

  180968

• Contact name

  Lakshminarayan Ranganath

• Contact email

  lakshminarayan.ranganath@rlbuht.nhs.uk

• Sponsor organisation

  The Royal Liverpool & Broadgreen University Hospitals Trust

• Duration of Study in the UK

  3 years, 0 months, 1 days

• Research summary

  This is a cross sectional study to determine age when ochronosis (dark pigment in connective tissues) begins in Alkaptonuria patients, by measuring ear cartlilage ochronosis, changes in gait and chamges in joint appearance.
  This is almost identical to the REC-Approved Natural History Study of Alkaptonuria,
  ( 07/H1002/111) where ear biopsies, blood/urine collections, MRI scans, Gait analysis and questionnaires; the R&DI at Royal Liverpool University Hospital advised us the do this application to ring fence the time-limited EC-funded SOFIA study unlike the relatively open-ended Natural History Study.

• REC name

  North West - Preston Research Ethics Committee

• REC reference

  15/NW/0749

• Date of REC Opinion

  13 Oct 2015

• REC opinion

  Further Information Favourable Opinion