SNOT: Sampling the Nose Of Toddlers and Young Children
Research type
Research Study
Full title
Nasal samples from healthy children: towards prevention of pneumonia
IRAS ID
236509
Contact name
Andrea Collins
Contact email
Sponsor organisation
Liverpool School of Tropical Medicine (LSTM)
Duration of Study in the UK
1 years, 6 months, 1 days
Research summary
•Streptococcus pneumoniae, is a type of bacteria that is an important cause of morbidity and mortality in children worldwide. At the same time healthy people often have this bacteria in the upper airway (nasopharynx) without any sign of disease (colonised) which is the main source for transmission to other people. The current pneumococcal conjugate vaccines (PCV) does not protect against all types of this group of bacteria. Novel vaccines aim to provide broader protection against pneumococcus and are currently being developed.
To test these new vaccines in future we need to learn more about how the body responds to this bacteria. We have observed in adults who are colonised for research purposes (experimentally) with this bacteria that a specific immune cell 'monocyte' is present in the airway that correlates with protection against carriage of this bacteria. Understanding whether these immune mechanisms control carriage in children is vital to the early testing of new vaccines as this is the target population for such vaccines.
REC name
North West - Liverpool Central Research Ethics Committee
REC reference
17/NW/0663
Date of REC Opinion
2 Jan 2018
REC opinion
Favourable Opinion