Sleep Quality and Melatonin Rhythms in Allergic Rhinitis
Research type
Research Study
Full title
Investigating Sleep Quality, Urinary Melatonin Metabolite Rhythms and Allergic Rhinitis Symptoms
IRAS ID
240226
Contact name
Debra/J Skene
Contact email
Sponsor organisation
University of Surrey
Duration of Study in the UK
0 years, 11 months, 28 days
Research summary
Allergic rhinitis (AR) is a very common disease, with around one in every five people in the UK being affected. Its symptoms get worse during the night and often cause sleep disruption and consequent daytime sleepiness. It is thought that the hormonal circadian rhythms and immune activity may both have effects on the allergic rhinitis symptoms and on sleep. However, to date little information is available.
In this study, we will investigate sleep quality, melatonin and cortisol rhythms and their association with AR symptom severity, using questionnaires, a wristwatch-type activity monitor and by collecting urine, blood and nasal mucus samples. Our study aims to better understand the role of melatonin in AR patients, results from this study may lead to further research developing a novel therapy for improving symptoms and sleep quality in AR patients.
We are asking patients with AR and their family members/partners who attend at the Royal Surrey County Hospital (Ear nose and throat; ENT Clinic and Immunology and Allergy Clinic ) to take part in this study. The research will last a year but each patient involvement would only be for approximately 2 weeks.REC name
London - Surrey Borders Research Ethics Committee
REC reference
18/LO/0275
Date of REC Opinion
15 Feb 2018
REC opinion
Favourable Opinion