SIOP CNS GCT II
Research type
Research Study
Full title
SIOP CNS GCT II. Prospective Trial for the diagnosis and treatment of children, adolescents and young adults with Intracranial Germ Cell Tumours
IRAS ID
83326
Contact name
James Nicholson
Contact email
Sponsor organisation
University of Münster
Eudract number
2009-018072-33
Duration of Study in the UK
5 years, 0 months, 0 days
Research summary
Intracranial germ cell tumours (GCTs) are rare tumours of childhood and adolescence that are varied with respect to their primary site, histology, biological profile and response to treatment. This trial is attempting to distinguish these different tumours by virtue of these factors, and treat accordingly. The philosophy is that the worse the prognosis (in relative terms), the more aggressive the treatment needs to be. In malignant GCTs, initial combination platinum-based chemotherapy will be administered prior to risk adapted radiotherapy and delayed tumour resection where required. In tumours with mixed histology, the therapeutic approach depends on the component with the highest grade of malignancy. For teratoma, no standardized treatment approach has been investigated in a multinational protocol to date.
REC name
East of England - Cambridge South Research Ethics Committee
REC reference
12/EE/0271
Date of REC Opinion
24 Sep 2012
REC opinion
Further Information Favourable Opinion