SINONIMS Version 1.0
Research type
Research Study
Full title
Study in Novel Neuro-muscular Imaging Biomarkers for Motor Outcome in Stroke
IRAS ID
249942
Contact name
Dipayan Mitra
Contact email
Sponsor organisation
Newcastle upon Tyne Hospitals NHS Trust
Duration of Study in the UK
2 years, 2 months, 0 days
Research summary
A common consequence of ischaemic stroke is the loss of lower limb function. This can lead to a stoke survivor being unable to continue to live an independent life. It would be beneficial to stroke survivors if clinicians could accurately predict recovery of lower limb function. An accurate prognosis would also enable treatment plans such as the content and duration of rehabilitation to be optimised. However, at present there is a lack of reliable methods for predicting recovery of movement after stroke. \n\nAdvanced magnetic resonance imaging (MRI) imaging can demonstrate the effect of stroke on the nerve pathways in the brain and the changes in the affected muscles in great detail. Advanced MRI has shown early promise in making recovery predictions in small-scale studies. Our research aims to build on this evidence and answer the question of whether advanced MRI can be used to predict how well stroke survivors will recover lower limb function.\n\nWe aim to study 30 participants who have had a first ever ischaemic stroke within the previous two to three weeks causing different degrees of stroke severity affecting the lower limb. They will undergo MRI brain and lower limb muscle scans lasting 40-45mins in a dedicated MRI facility in Newcastle University’s Campus for Ageing and Vitality. A test of physical strength and functional ability of the affected leg lasting about 30mins will be done around the time of the MRI scan and repeated 3 months after stroke. Analysis of our findings will determine whether advanced MRI scan findings are linked to the stroke survivors’ recovery of limb function.
REC name
North of Scotland Research Ethics Committee 1
REC reference
19/NS/0036
Date of REC Opinion
4 Mar 2019
REC opinion
Favourable Opinion