Silicolgel and breath gas levels
Research type
Research Study
Full title
The effect of an intestinal adsorbent on hydrogen and methane breath testing, in patients with abdominal and reflux symptoms, on long term proton pump inhibitor therapy
IRAS ID
264135
Contact name
Sam Treadway
Contact email
Sponsor organisation
Functional Gut Clinic
Clinicaltrials.gov Identifier
Duration of Study in the UK
0 years, 6 months, 1 days
Research summary
This is a pilot study looking at the effects of an intestinal adsorbent 'Silicol®gel' on breath gas levels, in patients on long term proton pump inhibitor (PPI) therapy.
Patients taking long term PPI therapy often have both persisting reflux symptoms and abdominal symptoms such as bloating, discomfort and altered bowel habits. Taking long term PPIs has also been associated with Small intestinal bacterial overgrowth (SIBO). SIBO can be diagnosed using hydrogen and methane breath testing. Symptoms of SIBO include, bloating, flatulence, belching, abdominal discomfort and change in bowel habit.
Silicol®gel is a certified Medical Device (Class II a). It works as an intestinal adsorbent. After silicol®gel is swallowed, it forms a protective and soothing coating over the lining of the stomach and intestines. Due to the adsorptive, it physically attracts and adsorbs most irritants, gases, toxins and pathogens. This renders them harmless so that they can be removed naturally through the intestines and out of the body.
We would like to study the effect of Silicol®gel on intestinal gases, measured by hydrogen and methane breath testing, in patients taking long term PPI therapy with abdominal and reflux symptoms.
REC name
Wales REC 7
REC reference
19/WA/0146
Date of REC Opinion
20 May 2019
REC opinion
Further Information Favourable Opinion