SIGNAL 2.0
Research type
Research Study
Full title
Stroke Investigation Group in North And central London (SIGNAL) 2.0: Prospective Observational Hospital-based Cohort Study
IRAS ID
318408
Contact name
David Werring
Contact email
Sponsor organisation
University College London
Duration of Study in the UK
2 years, 7 months, 31 days
Research summary
Globally, stroke is the second-leading cause of death and the third-leading cause of death and disability combined (1). In England, about one-third of people with stroke have a moderate or severe disability, one-third have a mild disability, and more than half of people with stroke experience anxiety or depression (2). Stroke can lead to profound disabilities that affect livelihoods and place a huge burden on care providers. Despite this, there is limited information about long-term recovery after stroke.
Stroke Investigation Group in North And central London (SIGNAL) is a registry of detailed patient data collected at each stage of the clinical pathway (from time of hospital admission up to 6 months post-stroke) for all patients presenting to the University College London Hospitals Hyperacute Stroke Unit (UCLH HASU) with stroke. SIGNAL is approved by the UCLH NHS Foundation Trust Governance Review Board as a continuous service evaluation of a comprehensive clinical care programme (service evaluation number: 5-201920-SE).
The UCLH HASU admits all patients with suspected stroke or TIA from a population of approximately 1.6 million residents in 5 North Central London (NCL) boroughs. This common starting point for NCL residents means that patient status at each follow-up time point can be compared to pre-stroke function to provide information about recovery after stroke for the NCL stroke population.
We plan to collect long-term follow-up data on the existing SIGNAL cohort using a range of patient-reported outcome measures to assess patterns of recovery after stroke. The data will be used to provide high-quality information about outcomes following presentation with specific stroke sub-types and will be linked to pre-stroke patient characteristics to investigate the long-term predictors of recovery after stroke.
REC name
London - South East Research Ethics Committee
REC reference
24/LO/0368
Date of REC Opinion
19 Jun 2024
REC opinion
Further Information Favourable Opinion