SERVED-Memory; version 2.0
Research type
Research Study
Full title
SERVED Memory: Feasibility study of Screening & Enhanced Risk Management for Vascular Event related Decline in Memory
IRAS ID
143243
Contact name
John Potter
Contact email
Sponsor organisation
Norfolk and Norwich University Hospital Trust
Duration of Study in the UK
2 years, 5 months, 27 days
Research summary
This study sets out to assess if the early detection of cognitive decline (memory problems) following a recent stroke or transient ischaemic attack (TIA or mini-stroke) can be prevented, slowed down or potentially reversed by addressing vascular risk factors (VRF) more intensively.
Vascular risk factors (e.g. high blood pressure, abnormal lipid levels, diabetes and atrial fibrillation) can contribute to the cognitive decline potentially resulting in vascular dementia as well as in mixed type dementia (Alzheimer’s and vascular dementia).
All adult patients admitted to the participating hospitals with confirmed stroke (first/recurrent) or TIA will be considered for the trial.
The initial study will assess the feasibility, acceptability and safety of an intervention which aims at controlling risk factors more intensively. We will estimate the potential impact in terms of clinical and cost effectiveness and the sample size for a future multicentre definitive study in the NHS setting.
A parallel observational study will be carried out to see if there is a link
between the number of vascular risk factors, their level of control and
subsequent cognitive function after stroke/TIA. The study has the potential to
influence clinical practice and improve the quality of life in this high risk patient population.REC name
East of England - Cambridge East Research Ethics Committee
REC reference
15/EE/0061
Date of REC Opinion
30 Mar 2015
REC opinion
Further Information Favourable Opinion